Please Note: All Cahn Litigation expert witness searches are customized to attorneys' precise specifications and preferences. Attorneys are encouraged to discuss search parameters with a Cahn search specialist.
The below expert witness bios represent a small fraction of those Enzymes experts known by Cahn Litigation Services. These bios are provided to give attorneys a sense of the Enzymes landscape.
This expert is currently Vice President for Research and Professor of Chemical and Biological Engineering at a prestigious university, and also holds joint appointments in the departments of Biomedical Engineering, Materials Science and Engineering, and Biology. This expert's skills are in enzyme technology, including preparation and use of enzymes in industrial and biomedical applications specific to generating enzymes for various basic and applied studies. Where enzymes are not commercially available, this expert clones, expresses, and purifies relevant enzymes using a number of different expression hosts (e.g., E. coli, bacillus, mammalian cells, etc.). This expert's research group includes chemical engineers, bioengineers, materials scientists, biologists, chemists and microbiologists - all focused on gaining a quantitative understanding of biological principles and applying them to advanced bioengineering, nanobiotechnology, drug discovery, and biomanufacturing. This expert has received numerous awards from the American Chemical Society, presently serves on Scientific Advisory Boards for several biotechnology companies and venture capital firms, and has cofounded a number of companies. This expert has a B.A. degree in Biochemistry and Chemistry and a Ph.D. in Biochemical Engineering, has published over 330 papers, and is a named inventor on nearly 40 patents and patent applications.
This expert holds a PhD and serves as Chair of the Department of Biochemistry and Professor in Fermentation Biochemistry at a major university. This expert brings to the table many years of experience in enzyme production, structure and function. This expert has extensive research experience with flavoproteins, recombinant protein expression, enzyme assays, and many other aspects of protein structure and function. Funded by the NIH, NSF, DOE and industry, this expert and research team have published ~200 peer-reviewed articles and chapters on the structure and mechanisms of proteins and enzymes. They have developed methods for bioinformatics analysis, cloning, expression testing, purification, and protein structure determination of eukaryotic proteins, human mitochondrial proteins, and integral membrane proteins. Under this expert's direction, the Center cloned ~10,000 genes from model eukaryotes, purified over 1,000 different proteins, and maintained active collaborations with over 200 scientists world-wide. A leader in both the discovery and the biochemical and structural studies of diiron enzymes, this expert's research contributions include pioneering efforts on soluble methane monooxygenase. As a new faculty member, this expert initiated work on toluene 4-monooxygenase (T4MO) and the group established the identity of all four proteins in the T4MO complex, established the first successful mutagenesis system for any diiron enzyme, and showed how to engineer the active site to change regiospecificity while maintaining kcat, KM and coupling. They obtained structures of all individual members of protein complex, and importantly, high resolution structures of complexes that show how different protein-protein interactions successively rearrange the active site to promote efficient catalysis. This expert is the named inventor on seven US patents in the area of biotechnology surrounding the use of enzymes, and has participated in the drafting and in negotiations with the US Patent Office. This expert has been deposed but has not had the opportunity to testify.
With a Ph.D. in organic chemistry, post-doctoral work in molecular biology, and industrial experience combining process chemistry, organic synthesis, biotechnology, biocatalysis, plus natural product fermentation and downstream processing, this expert provides a unique combination of skills. After obtaining a Ph.D. in synthetic organic chemistry, this expert joined a company where work led to a number of patents covering the enzymatic resolution of pharmaceutical intermediates, one of which earned royalties of several million dollars. In this particular project, this expert was the chief technical witness in a patent interference suit. Following the success of the suit, this expert was invited to establish a new group within a major Chemical Process Development company. The group successfully introduced biocatalysis in over a dozen projects at scales ranging from lab-bench scale synthesis of drug metabolites for Drug Discovery groups, to GMP pilot-plant batches providing intermediates for clinical material. This included the use of a non-aqueous enzymatic step in the synthesis of an antifungal agent. Under this expert's leadership, the group filed 13 patent disclosures and produced a total of 37 public presentations and publications - an unusual accomplishment for an industrial development group. Shortly after, this expert moved to a major pharmaceutical company and became Director of Fermentation and Biocatalysis Development. This expert's group handled chemical process development, molecular biology, industrial fermentation, and GMP analytical services, supporting both Discovery and Production. This expert then established a venture, providing new and small companies with technical strategy, IP analysis, and CTO-level management across a range of disciplines covering process chemistry, molecular biology, biotransformations & biocatalysis, industrial biotech, plus fermentation of natural products and recombinant enzymes. This expert brings 40 years of experience in the field of biocatalysis and the expression of enzymes (and other proteins) as well as metabolic pathways. This expert has considerable experience in using enzymes in commercial processes, fermentation development, and co-factor recycling. This expert has appeared in both federal and State court and been deposed and crossed multiple times.
This expert has been working with enzymes, including digestive ones, for many years. This expert has extensive experience, both research and litigation support, in drug delivery, including oral administration using tablets and capsules. This experience understands various coatings, such as enteric and modified-release ones.
This expert has started six pharmaceutical companies and has been a scientific advisor, consultant, and/or director for numerous pharmaceutical, medical device, and biotechnology companies, as well as an expert witness in many pharmaceutical patent infringement litigations. This expert has authored numerous scientific papers and 32 issued U.S. patents, given a plethora of invited lectures, and is a member of over a dozen scientific journal editorial boards. This expert holds a Ph.D. in Chemical Enzymology and an M.S. in Chemistry.