With a Ph.D. in organic chemistry, post-doctoral work in molecular biology, and industrial experience combining process chemistry, organic synthesis, biotechnology, biocatalysis, plus natural product fermentation and downstream processing, this expert provides a unique combination of skills. After obtaining a Ph.D. in synthetic organic chemistry, this expert joined a company where work led to a number of patents covering the enzymatic resolution of pharmaceutical intermediates, one of which earned royalties of several million dollars. In this particular project, this expert was the chief technical witness in a patent interference suit. Following the success of the suit, this expert was invited to establish a new group within a major Chemical Process Development company. The group successfully introduced biocatalysis in over a dozen projects at scales ranging from lab-bench scale synthesis of drug metabolites for Drug Discovery groups, to GMP pilot-plant batches providing intermediates for clinical material. This included the use of a non-aqueous enzymatic step in the synthesis of an antifungal agent. Under this expert's leadership, the group filed 13 patent disclosures and produced a total of 37 public presentations and publications - an unusual accomplishment for an industrial development group. Shortly after, this expert moved to a major pharmaceutical company and became Director of Fermentation and Biocatalysis Development. This expert's group handled chemical process development, molecular biology, industrial fermentation, and GMP analytical services, supporting both Discovery and Production. This expert then established a venture, providing new and small companies with technical strategy, IP analysis, and CTO-level management across a range of disciplines covering process chemistry, molecular biology, biotransformations & biocatalysis, industrial biotech, plus fermentation of natural products and recombinant enzymes. This expert brings 40 years of experience in the field of biocatalysis and the expression of enzymes (and other proteins) as well as metabolic pathways. This expert has considerable experience in using enzymes in commercial processes, fermentation development, and co-factor recycling. This expert has appeared in both federal and State court and been deposed and crossed multiple times.
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